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Claudia mori alzheimer8/11/2023 ![]() ![]() Due to its multifactorial nature, the gradual cognitive decline is associated with the interaction of multiple pathological alterations, including brain atrophy, amyloid plaques deposition, and neurofibrillary tangles formation, which ultimately lead to a clinical diagnosis of dementia. Our results confirm TMS efficacy in improving global cognitive functioning in mild-to-moderate AD patients, but also highlight the flaws of current protocols characteristics, including a possible lack of sufficient personalization in stimulation protocols.Īlzheimer’s disease (AD) represents the most common type of neurodegenerative disease. ![]() We then compared the effect sizes of subsets of studies based on additional protocol characteristics (frequency, duration of intervention, number of stimulation sites, use of concomitant cognitive training and patients’ educational level). Differently from prior published meta-analytic work, we investigated whether protocols that considered participants-specific neuroimaging scans for the selection of individualized stimulation targets held more successful outcomes compared to those relying on a generalized targeting selection criteria. To answer this query, we conducted a systematic literature search in PubMed, PsycINFO and Scopus databases and meta-analysis of studies published in the last 10 years (2010–2021) according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Nevertheless, we currently lack agreement between research studies on the optimal stimulation protocol yielding the highest efficacy in these patients. Among those, transcranial magnetic stimulation (TMS) has been shown a promising, safe and noninvasive intervention to improve global cognitive functioning. Although our knowledge on the causes of AD remains limited and no curative treatments are available, several interventions have been proposed in trying to improve patients’ symptomatology. Alzheimer’s disease (AD) represents the most common type of neurodegenerative disorder. ![]()
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